HFE Gene Mutations in Cryptogenic Cirrhosis Patients

HFE Gene Mutations in Cryptogenic Cirrhosis Patients

In Western countries, HFE-linked hereditary hemo-chromatosis (HH) is considered to be the most common cause of iron overload. The HFE gene, first identified in 1996, is located on the short arm of chromosome 6. The majority of patients with phenotypic HH are homozy-gous for the C282Y mutation, a major mutation of the HFE gene, whereas compound heterozygosity (C282Y/ H63D) is found in patients w...

hfe gene mutations in cryptogenic cirrhosis patients

HFE Gene Mutations, Iron Overload and Cryptogenic Liver Cirrhosis

The diagnosis of cryptogenic cirrhosis is an exclusion diagnosis. It has become far less frequent over the last decades , but it still effects a significant number of patients. Many previously unknown chronic liver disease entities were described in the second half of the last century, including chronic viral hepatitis B, C and D, along with refined criteria for diagnosing autoimmune hepatitis ...

hfe gene mutations, iron overload and cryptogenic liver cirrhosis

author’s reply: hfe gene mutations (c282y and h63d) in a group of patients with cryptogenic cirrhosis